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(MSCDFSM) Nutritional Biochemistry (TMA-2) ANSWER 2017

c) What do you understand by the term de novo synthesis for purine synthesis?
Give the steps involved in de novo synthesis for purine nucleotides.

ANS- Nearly all organisms can make the purine and pyrimidine nucleotides via so-called de novo biosynthetic pathways. (De novo means "anew"; a less literal but more apt translation might be "from scratch" because de novo pathways are metabolic sequences that form complex end products from rather simple precursors.) Many organisms also have salvage pathways to recover purine and pyrimidine compounds obtained in the diet or released during nucleic acid turnover and degradation.

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